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Reduced appetite or loss of appetite (anorexia) in cats
When to visit the vet?
Urgent see a veterinarian within 24 hours
RED FLAG for complete refusal to eat >24 h (especially overweight cats), in kittens, with simultaneous jaundice, vomiting, dehydration, weakness, or shortness of breath.
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Definition
Can Occur with the Following Diseases:
- Adenocarcinoma of the Parotid Gland or Mandibular Gland (Salivary Gland Cancer)
- Adenocarcinoma of the Intestine (Intestinal Cancer Originating from the Glandular Cells)
- Amitraz Toxicosis (Poisoning from Tick Collar)
- Anal Gland Carcinoma (Anal Gland Cancer)
- Anxiety and Compulsive Disorders
- Arsenic Intoxication (Arsenic Poisoning)
- Aspiration Pneumonia (Pneumonia after Inhaling Food or Vomit)
- Ascites (Fluid Accumulation in the Abdomen)
- Autoimmune Hemolytic Anemia (Anemia Related to the Immune System)
- Azotemia, Uremia (High Levels of Nitrogenous Metabolic Products in the Blood)
- Bacterial Pneumonia
- Bartonellosis, Bacterial Infection Caused by Bartonella Henselae (Cat Scratch Disease)
- Chlamydiosis (Bacterial Infection of the Upper Respiratory Tract with Chlamydia Species)
- Chronic Hypertrophic Pylorus Gastropathy, CHPG (Narrowing of the Gastric Outlet)
- Chronic Hepatitis (Chronic Liver Inflammation)
- Clostridium Perfringens Enteropathy (Bacterial Intestinal Infection Caused by Clostridium Perfringens)
- Clostridium Piliforme Infection (Bacterial Infection with Clostridia, Tyzzer's Disease)
- Colibacillosis (Bacterial Intestinal Infection with Escherichia Coli)
- Irritable Bowel Syndrome (IBS in Cats)
- Cytauxzoonosis (Parasitic Skin Disease Caused by Cytauxzoon Species)
- Intussusception (Intestinal Invagination)
- Dementia (Memory Loss)
- Deoxynivalenol Mycotoxicosis, DON (Poisoning with the Fungal Toxin from Fusarium Species, Deoxynivalenol)
- Digoxin Intoxication (Poisoning by the Drug Digoxin)
- Encephalitis (Brain Inflammation)
- Erythrocytes with Heinz Bodies (Anemia Due to Red Blood Cell Damage)
- Exocrine Pancreatic Insufficiency, EPI (Pancreatic Hypofunction)
- Feline Calicivirus Infection, FCV (Cat Flu, Calicivirus Infection)
- Feline Dysautonomia, Key-Gaskell Syndrome (Malfunction of the Autonomic Nervous System)
- Feline Enteric Coronavirus Infection, FECV (Intestinal Infection with Coronavirus)
- Feline Herpesvirus Infection, FHV (Cat Flu Caused by Herpesvirus Infection)
- Feline Idiopathic Cystitis, FIC (Non-infectious Cystitis)
- Feline Infectious Anemia, Haemobartonellosis, Hemoplasmosis (Bacterial Blood Infection Caused by Mycoplasma Species)
- Feline Infectious Peritonitis, FIP (Infectious Inflammation of the Peritoneum in Cats)
- Feline Neonatal Isoerythrolysis, FNI (Destruction of Red Blood Cells in Newborn Cats, Fading Kitten Syndrome)
- Feline Parvovirus infection, FPV, Feline Panleukopenia (Feline distemper, Panleukopenia)
- Feline Spumavirus Infection, FSV (Feline Spumavirus Infection)
- Feline Immunodeficiency Syndrome, FIV Infection (Feline AIDS)
- Feline Small Intestinal Lymphoma (Small Intestinal Cancer in Cats)
- Gastritis (Inflammation of the Stomach Lining)
- Astrovirus Infection Gastroenteritis (Intestinal Infection Caused by the Astrovirus)
- Gastrointestinal Mast Cell Tumors (Mast Cell Tumors in Abdominal Organs)
- Gastrointestinal Motility Disorders (Movement Disorders of the Gastrointestinal Tract)
- Giardiasis (Parasitic Intestinal Infection with Giardia)
- Feline H1N1 Influenza Infection (Cat Flu, Swine Influenza Virus Infection)
- Hepatic Encephalopathy (Impaired Brain Function Due to Liver Disease)
- Hepatotoxins (Liver Toxins)
- Hepatocellular Adenoma, Liver Cell Adenoma (Liver Tumor Originating from the Liver Cells)
- Hepatocellular Carcinoma (Liver Cancer Due to a Carcinoma)
- Hernia Umbilicalis (Umbilical Hernia)
- Hypereosinophilic Syndrome (Overproduction of Special White Blood Cells of the Immune System in the Bone Marrow)
- Hyperthyroidism (Overactive Thyroid)
- Hypertension (High Blood Pressure)
- Hypervitaminosis A (Vitamin A overdose poisoning)
- Hypervitaminosis D (Vitamin D overdose toxicity)
- Hypoadrenocorticism (Addison's Disease)
- Hypokalemia (Low Potassium Level in the Blood)
- Hypocalcemia (Low Calcium Level in the Blood)
- Hypoparathyroidism (Low Production of Parathyroid Hormone in the Parathyroid Glands)
- Ibuprofen Poisoning
- Ileus (Intestinal Obstruction)
- Immunodeficiency (Weak Immune System Due to Hereditary Diseases, Primary Immunodeficiency)
- Infection with Staphylococcus species, e.g. Staphyloccocus aureus (Bacterial infection with staphylococci)
- Infections with Anaerobic Bacteria (Bacterial Infections Caused by Anaerobes)
- Infectious Endocarditis (Heart Valve Infection)
- Carcinoid Tumors and Carcinoid Syndrome (Carcinoid Cancer)
- Coccidiosis (Parasitic intestinal infection caused by coccidia)
- Conjunctivitis
- Constipation, Obstipation (constipation)
- Cryptosporidiosis (Parasitic intestinal infection with Cryptosporidium species)
- Cutaneous Sporotrichosis (Fungal Infection of the Skin with Sporothrix Species)
- Cutaneous and mucocutaneous squamous cell carcinoma (Skin and mucous membrane cancer)
- Leishmaniasis (Parasitic infection caused by Leishmania species)
- Leptospirosis (Bacterial infection caused by Leptospira species)
- Pulmonary Adenocarcinoma, Bronchial Carcinoma (Lung Cancer Originating from Glandular Cells of the Airways)
- Lung Lobe Torsion (Twisting of a Lung Lobe)
- Lymphadenitis (Lymph Node Inflammation)
- Lymphadenopathy (Swelling of one or more Lymph Nodes)
- Lymphoma, Lymphosarcoma (cancer caused by blood cells, the lymphocytes)
- Stomach worm infection, Ollulanosis (Parasitic infection of the stomach caused by Ollulanus species)
- Megacolon (Colon Enlargement)
- Megaloblastic Macrocytic Anemia (Anemia Due to Maturation Disorders of Red Blood Cells)
- Mitral valve dysplasia Mitral valve endocardiosis (malformation of the heart valve between the left atrium and left ventricle)
- Muscle Rupture (Torn Muscle)
- Myocarditis (Inflammation of the Heart Muscle)
- Nasal adenocarcinoma (cancer of the nasal and paranasal sinuses originating from the mucous glands)
- Nasal chondrosarcoma (cancer of the nasal and paranasal sinuses originating from cartilage tissue)
- Nasal fibrosarcoma (cancer of the nasal and paranasal sinuses originating from soft tissue)
- Neuroendocrine tumor, Apudoma (intestinal tumor originating from hormone-producing cells)
- Neuropathic Pain (Pain Due to Injuries of the Nervous System)
- Opisthorchis Felineus infection, Opisthorchiasis infection (Parasitic infection with the cat liver fluke)
- Esophagitis (Inflammation of the Esophagus)
- Esophageal obstruction (blockage of the esophagus)
- Osteosarcoma (Bone Cancer)
- Pancreatic Adenocarcinoma (Pancreatic Cancer)
- Pancreatitis (Inflammation of the Pancreas)
- Panosteitis (Bone and Periosteal Inflammation)
- Papilledema (Swelling at the junction of the optic nerve and the retina)
- Paraneoplastic Syndrome (Side effects of cancer)
- Perianal Fistula (Chronic Inflammatory Condition of the Anal Region)
- Pericardial effusion (fluid accumulation in the pericardium)
- Plague, Yersinia Pestis Infection (Bacterial Infection Caused by Yersinia Species)
- Plumbism (Lead Poisoning)
- Portal Hypertension (High Blood Pressure in the Portal Vein to the Liver)
- Portosystemic shunt, Intrahepatic arteriovenous malformation (Liver shunt)
- Postpartum metritis of the uterus (Bacterial infection of the uterus after birth)
- Prostatitis and Prostatic Abscess
- Pyometra (Uterine Infection)
- Pyruvate Kinase Deficiency, PK (Pyruvate Kinase Deficiency)
- Rabies
- Renal Adenocarcinoma (Kidney Cancer)
- Renomegaly (Kidney Enlargement)
- Restrictive Cardiomyopathy (Stiffening of the Heart Muscle)
- Rhinitis and Sinusitis (Nasal and Sinus Inflammatory Conditions)
- Rotavirus Gastroenteritis (Intestinal Infection Caused by Rotavirus)
- Sarcocystosis (Parasitic intestinal infection with Sarcocystis species)
- Sepsis, Septicemia, and Bacteremia (Bacterial Infection of the Blood, Blood Poisoning)
- Synovial sarcoma (joint cancer originating from the synovial membrane)
- Tracheal perforation (Hole in the trachea)
- Ulcus ventriculi, Ulcus duodeni (Gastric and duodenal ulcers)
- Vestibular Syndrome (Balance System Disorder)
- Dental Problems
- Cirrhosis and Fibrosis of the Liver (Loss of Functional Liver Tissue)
- Cyclic Hematopoiesis (Blood Disorder Related to FeLV Infection)
- Acute Lymphoblastic Leukemia, ALL (Acute Leukemia)
- Ancylostomiasis (Parasitic Intestinal Infection with Hookworms, Ancylostoma Species)
- Interstitial Pneumonia (Inflammation of the Pulmonary Connective Tissue)
- Fungal Infection of the Lower Urinary Tract
- Retained placenta (afterbirth behavior)
- Hyperparathyroidism (Abnormally High Parathyroid Hormone Level, Overactive Parathyroid Glands)
- Acute Kidney Injury, AKI (Acute Renal Failure)
- Salmonellosis (Bacterial Intestinal Infection Caused by Salmonella Species)
- Mastitis (Bacterial infection of the mammary glands)
- Actinomycosis (Bacterial Infection Caused by Bacteria of the Genus Actinomyces)
- Lyme disease (Bacterial infection caused by Borrelia burgdorferi)
- Tularemia (Bacterial infection caused by Francisella species)
- Bordetellosis (Bacterial Infection with Bordetella Bronchiseptica)
- Brucellosis (Bacterial Infection with Brucella Species)
- Campylobacteriosis (Bacterial Infection with Campylobacter Species)
- Q Fever, Coxiellosis due to infection with the bacterium Coxiella burnetii (Bacterial infection with Coxiella species)
- Ehrlichiosis (Bacterial Infection with Ehrlichia Species)
- Listeriosis (Bacterial infection with Listeria species)
- Streptococcosis (Bacterial infection with Streptococci)
- Babesiosis (Parasitic Infection Caused by Babesia Species)
- Helicobacteriosis (Bacterial Stomach Infection with Helicobacter Species)
- Herniated Disc (Intervertebral Disc Disease)
- Peritonitis (Inflammation of the Abdominal Cavity)
- Biliary Peritonitis (Peritonitis Due to Gallbladder Rupture)
- Hyperviscosity Syndrome (Blood Thickening Due to Blood Proteins)
- Polycythemia Vera (Blood Thickening Due to Increased Production of Blood Cells in the Bone Marrow)
- Pulmonary thromboembolism (blood clot in the lung)
- Inflammatory Bowel Disease, IBD (Chronic Inflammatory Bowel Disease)
- Chronic Renal Insufficiency (Chronic Kidney Disease)
- Paralytic Ileus (Intestinal Obstruction Due to Paralysis of the Intestinal Muscles)
- Pectus Excavatum (Deformed Sternum, Funnel Chest)
- Colitis and Proctitis (Inflammation of the Colon and Rectum)
- Otitis Media and Otitis Externa (Inflammatory Conditions of the Middle Ear and the External Auditory Canal)
- Osteomyelitis, Osteitis (Inflammation of Bone Tissue)
- Glaucoma (Elevated Intraocular Pressure)
- Dilated Cardiomyopathy (Enlarged Heart Chambers)
- Steatitis (Inflammation of Fatty Tissue)
- Hepatic Lipidosis (Fatty Liver)
- Pleural effusion (fluid accumulation in the chest between the parietal and visceral pleura)
- Hydronephrosis (Fluid Accumulation in the Kidney, Urine Congestion in the Renal Pelvis)
- Cholecystitis and Cholangitis (Gallbladder and Bile Duct Inflammation)
- Cholangiocarcinoma, Cholangiocellular Carcinoma (Bile Duct Cancer)
- Skin Ulcer (Cutaneous Ulcer)
- Bladder Rhabdomyosarcoma (Bladder Cancer Originating from the Bladder Muscle)
- Urolithiasis (Urinary Tract Stones, Stones and Crystals in the Renal Pelvis, Ureter, Bladder and/or Urethra, as Well as in the Urine)
- Cleft Lip, Jaw, Palate, LCP (Harelip)
- Mucocutaneous Plasmacytoma (skin cancer originating from plasma cells, a type of white blood cells)
- Paraneoplastic Skin Syndrome (Skin changes related to cancer)
- Chemodectoma (Heart and Carotid Artery Tumor)
- Hypertrophic Cardiomyopathy (Heart Disease Due to Thickening of the Heart Muscle)
- Cardiac Hemangiosarcoma (Heart Cancer, Blood Vessel Tumor)
- Orthopox infection (skin infection caused by poxvirus)
- Feline Leukemia Virus (FeLV) Infection (Feline Leukemia Virus)
- Papillomatosis (infection with the wart virus, Papillomavirus)
- Septic Arthritis (Infectious Joint Inflammatory conditions)
- Prostate Adenocarcinoma (Prostate Cancer)
- Multiple Myeloma (Bone Marrow Cancer)
- Pulmonary lymphomatoid granulomatosis (Cancerous lymphatic cells in the lungs)
- Granulomatous Hepatitis (Liver Inflammation with Nodule Formation)
- Acute Liver Insufficiency (Acute Liver Failure)
- Hernia Inguinalis (Inguinal Hernia)
- Fungal Pneumonia, Mycotic Pneumonia (Pneumonia Due to Fungal Infection)
- Chylothorax (Lymphatic Effusion in the Pleural Space in the Chest)
- Squamous cell carcinoma of the nasopharynx (nasal and paranasal sinus cancer originating from skin and mucous membrane cells)
- Pheochromocytoma (Adrenal Gland Cancer)
- Anaplasmosis (Parasitic Infection Caused by Anaplasma Species)
- Toxoplasmosis (Parasitic infection with Toxoplasma species)
- Gastrointestinal infection with Physaloptera species (Parasitic gastrointestinal infection caused by stomach worms, roundworm infection)
- Mycotic Pneumonia (Fungal Lung Infection)
- Blastomycosis (Fungal Infection Caused by Blastomyces Species)
- Histoplasmosis (Fungal Infection with Histoplasma Species)
- Amyloidosis (Protein Deposits in the Body)
- Hepatic Amyloidosis (Protein Deposits in the Liver)
- Malignant Fibrous Histiocytoma (Giant Cell Tumor)
- Gastroesophageal Reflux (GER) (Acid Reflux)
- Pseudopregnancy, Lactatio Falsa (False Pregnancy)
- Hypothyroidism (Underactive Thyroid)
- Ketoacidotic Coma (Metabolic Derailment in Diabetes, Diabetic Coma Due to Increased Fat Breakdown)
- Systemic lupus erythematosus (Systemic autoimmune disease)
- Thymoma (Tumor of the thymus gland)
- Adenocarcinomas of the Skin (Tumors of the Sweat and Sebaceous Glands)
- Esophageal diverticulum (localized pouch in the esophageal wall)
- Splenic Torsion (Twisted Spleen)
- Esophageal stricture (narrowing of the esophagus)
- Sago Palm Poisoning (Poisoning from Eating Parts of a Sago Palm)
- Tremorgenic Mycotoxins (Fungal Toxin Poisoning)
- Intoxication / poisoning due to the insecticides organophosphate and carbamate (poisoning from toxins used to control insects)
- Idiopathic Pulmonary Fibrosis (Hardening of the Lungs)
- Bile Duct Obstruction
- Distortion and Distension (Sprains and Strains of Ligaments and Joints)
- Diabetes Insipidus (Water Diabetes)
- Zinc Intoxication (Zinc Poisoning)
- Lingual squamous cell carcinoma (tongue cancer)
- Hiatal Hernia (Diaphragmatic Hernia at the Passage of the Esophagus into the Abdominal Cavity)
- Gastric foreign body (foreign body in the stomach)
- Trichobezoars (Hairballs in the Stomach)
- Feline Spongiform Encephalopathy, FSE (Brain Inflammation Caused by Pathogenic Proteins, Prions)
- Cyclic Neutropenia (Chediak-Higashi Syndrome)
- Superficial Necrolytic Dermatitis (Degenerative Skin Disease)
- Hepatic Coagulopathy (Blood Coagulation Disorder, Liver-Related)
- Pancytopenia (Global Disorder of Blood Formation)
Basics and possible causes
Nutrition plays a central role in every cat’s life, and a loss of appetite can be due to a variety of reasons. Generally, causes of loss of appetite can be divided into two categories: non-medical causes and medical causes.
Non-medical causes include changes in the cat’s environment or routine that can lead to stress. This could be the arrival of a new pet, a move, or unfamiliar noises and smells. Such changes can cause stress, which in turn can lead to temporary loss of appetite.
Medical causes are diverse and can range from dental pain, infectious diseases, kidney diseases, liver problems, to serious illnesses like cancer. Parasite infestation or gastrointestinal problems can also significantly affect a cat’s appetite.
Further attention should be paid to feeding habits. A change in food or poor food quality can also lead to a refusal to eat. Sensitive cats often react to the slightest change in their diet.
Typical accompanying symptoms
- Weight loss: One of the most obvious consequences of loss of appetite is weight loss. This can occur quickly, especially in smaller or already thin cats.
- Lethargy: Cats that do not consume enough food may appear lethargic or listless. They often withdraw and show less interest in their usual activities.
- Changes in coat: A lack of nutrients can lead to a dull, lackluster coat. The cat may also shed more hair than usual.
- Dehydration: If the cat stops drinking as well as eating, this can lead to dehydration, which manifests as dry mucous membranes or a poor general condition.
- **Vomiting** or **diarrhea**: Accompanying gastrointestinal symptoms such as **vomiting** or **diarrhea** can be both a cause and a consequence of loss of appetite.
- **Behavioral changes**: A sick or stressed cat may behave unusually, e.g. hide more or react more aggressively.
When to see a vet?
A vet visit should be considered if the loss of appetite persists for more than 24 to 48 hours, especially in young cats or those with existing health conditions. Cats that do not eat for an extended period risk developing hepatic lipidosis, a potentially life-threatening condition.
If the loss of appetite is accompanied by other serious symptoms such as severe vomiting, diarrhea, lethargy, or obvious pain, an immediate vet visit is necessary. Even if the cat shows signs of dehydration, such as sunken eyes or sticky mucous membranes, quick action is required.
Chronic loss of appetite, accompanied by progressive weight loss or other health impairments, also requires a thorough veterinary examination to rule out underlying problems.
Symptom recognition for the pet owner and veterinary diagnostic procedure
For pet owners, it is important to closely observe their cat’s eating habits. A sudden aversion to food, changed preferences, or a complete refusal to eat are clear signs that something is wrong.
The veterinarian will first take a thorough medical history to narrow down the possible causes. This includes asking about changes in the cat’s environment, diet, and general living conditions. A physical examination is essential to detect signs of dehydration, dental diseases, or other physical abnormalities.
Depending on the suspicion, further diagnostic measures such as blood tests, X-rays, ultrasound, or testing for infectious diseases may be necessary. These tests help to rule out or confirm organic causes and to assess the cat’s general health.
What the pet owner can do and professional therapy options
As a first measure, the pet owner can try to offer the cat particularly palatable and easily digestible food. This includes, for example, special diet foods or wet food, which is often better accepted than dry food.
Stressors should be reduced as much as possible. A quiet, safe feeding place without distractions can help. The cat should not be forced to eat, as this can cause additional stress.
It is important to ensure fluid intake. If the cat does not drink, it may be helpful to carefully administer water with a syringe or offer a mixture of water and wet food.
Long-term solutions depend on the underlying cause. In cases where medical problems have been diagnosed, adherence to the treatment plan recommended by the veterinarian is crucial. This may include administering medication, special diets, or other therapeutic measures.
Regular follow-up examinations with the veterinarian help to monitor progress and adjust therapy if necessary. The pet owner should closely observe and document any changes in their cat’s behavior or health status to share this information with the veterinarian.
Outlook on current research
Research into loss of appetite in cats is increasingly focusing on detecting subtle behavioral changes that can serve as early indicators of serious health problems. Researchers are investigating how genetic factors, environmental conditions, and individual temperament differences influence eating behavior. The development of technologies such as wearable activity trackers and feeders that monitor eating behavior offers new opportunities to detect and understand the signs of anorexia early.
An interesting research direction deals with the role of neurotransmitters in the brain that regulate appetite. Studies show that changes in the serotonin and dopamine systems in cats can be associated with loss of appetite. New medications targeting these systems could potentially offer a future treatment option for cats with anorexia.
Another research area investigates the influence of stress and psychological factors on cats’ appetite. Chronic stress, for example due to changes in the home environment or conflicts with other pets, can lead to a reduction in appetite. Scientists are working to identify stress markers in the blood that could serve as indicators of stress-related loss of appetite.
Furthermore, there are advances in the study of appetite stimulants. Phytochemical compounds from plants and synthetic peptides are being tested for their ability to safely stimulate appetite in cats. Such approaches could be particularly important for older cats or those with chronic illnesses who require increased caloric intake.
Finally, the role of the gut microbiota as an influencing factor on appetite is increasingly recognized. Studies suggest that an unbalanced microbiome can negatively affect eating behavior and the general well-being of cats. Researchers are investigating how probiotics and prebiotics can contribute to appetite regulation by improving gut health.