Urinary Obstruction (Urethral Obstruction)

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In case of a partial or complete urinary tract obstruction, urination becomes hardly possible or impossible.
Unfortunately, this emergency occurs not infrequently in male cats.

Urinary tract obstruction, medically referred to as urethral obstruction, represents an acute emergency situation in veterinary medicine. It involves a partial or complete blockage of the urethra, which prevents the outflow of urine from the bladder. This condition affects both dogs and cats, with male animals being significantly more frequently affected due to their anatomically longer and narrower urethra. Particularly in male cats (tomcats), urethral obstruction is one of the most common urological emergencies.

The anatomy of the urinary tract plays a crucial role in the development of an obstruction. In cats, the urethra narrows significantly in the penile area, which is a predisposing factor for obstructions. In dogs, the diameter of the urethra varies depending on the breed, with smaller breeds tending to have a narrower urethra and thus being more susceptible to blockages.

An untreated urinary tract obstruction leads to life-threatening complications within 24-48 hours, as substances that need to be excreted in urine can no longer be eliminated and accumulate in the blood. This leads to metabolic disturbances such as hyperkalemia, azotemia, and metabolic acidosis, which, if left untreated, can lead to the animal’s death. Additionally, the pressure in the bladder continuously increases, which can lead to tissue damage, bladder rupture, and urine leakage into the abdominal cavity.

Causes

Generally, the more or less complete blockage of the urethra is caused by accumulations of crystals or urinary stones. Cell accumulations also play a role.
A diet of purely dry food and insufficient exercise, as well as obesity, contribute to the increasingly diagnosed urethral obstruction.
In rare cases, tumors and other diseases such as spinal cord injuries (slipped disc) and other neurogenic bladder emptying disorders can also prevent regulated urination.

Supplement

The causes of urinary obstruction are diverse and partly differ between dogs and cats. In cats, the most common cause is Feline Idiopathic Cystitis (FIC), which is associated with inflammation of the bladder wall and the formation of inflammatory products that can clog the urethra. Furthermore, urinary stones play a central role, with struvite stones (magnesium ammonium phosphate) and calcium oxalate stones being predominantly found in cats.

In dogs, urinary stones are also a common cause of urethral obstructions, with different types of stones dominating depending on the breed. Dalmatians, for example, tend to form urate stones, while cystine stones are more common in Schnauzers. Struvite stones occur in both species and are often associated with bacterial urinary tract infections.

Other possible causes of urinary obstruction include:

  • Crystalluria: Accumulation of crystals in the urine that can form larger conglomerates
  • Urethral plugs: Blockages consisting of a mixture of proteins, cells, and crystals, especially common in male cats
  • Tumors of the urethra or surrounding tissues
  • Traumatic injuries followed by scarring and narrowing of the urethra
  • Neurological disorders that can lead to functional obstruction
  • Prostatic hyperplasia or inflammation in unneutered male dogs

Predisposing factors for the development of urinary obstruction are obesity, lack of exercise, exclusive dry food diet, insufficient water intake, and chronic stress, especially in cats. These factors lead to concentrated urine, which promotes the formation of crystals and stones.

Symptoms

  • Frequent attempts to urinate
  • Sometimes the litter box is not used
  • Usually only dropwise or no urination at all
  • Expressions of pain
  • Frequent licking of the penis

If the blockage of the urethra is not resolved promptly, consequential damage to the kidneys occurs, as well as increasing poisoning due to unexcreted components of the urine (uremia).
The clinical picture worsens within hours and kidney damage is imminent. The following occurs:

  • Disturbance of general well-being
  • Fever
  • Lethargy
  • Vomiting
  • Sometimes dropwise blood discharge
  • Bladder rupture
  • Shock

Supplement

The clinical signs of urinary obstruction typically develop progressively and can vary depending on the severity and duration of the obstruction. In the early stages, affected animals often show the following symptoms:

Initially, repeated, unsuccessful attempts by the animal to urinate (stranguria) are observed. The animals typically assume the posture for urination but produce no urine or only drops. This behavior is often accompanied by clear expressions of pain. Cats often meow pitifully during the attempt to urinate. Dogs whine or yelp.

Affected animals also show an increased frequency of urination attempts (pollakiuria) and may seek unusual places to urinate. In cats, this often manifests as avoiding the litter box and instead trying to urinate in other areas of the home. Another characteristic symptom is intense licking in the genital area, indicating pain and discomfort.

As the duration of the obstruction progresses, the general condition deteriorates rapidly. The animals become increasingly lethargic, refuse food and water, and may vomit. On palpation, the bladder is tightly filled, hard, and painful. With prolonged duration of the obstruction, systemic symptoms of uremia occur with dehydration, hypothermia or fever, tachycardia, and eventually clouding of consciousness leading to coma.

In some animals, bloody urine (hematuria) may also be observed, indicating inflammation or injury to the urinary tract. In advanced cases, the high pressure in the bladder can lead to rupture, resulting in life-threatening uremia and peritonitis.

The symptoms of urinary tract obstruction always represent an absolute emergency and require immediate veterinary intervention, as death due to kidney failure and metabolic imbalances can occur within 24-48 hours if left untreated.

First Aid

Treatment by the pet owner is not possible. As soon as you notice the problem, take your pet to a veterinarian.

  • Keep your pet warm
  • Do not attempt to express the bladder
  • Do not administer diuretic medications or teas.

Diagnosis

The diagnosis of a urinary tract obstruction is based on a combination of medical history, clinical examination, and further diagnostics. The veterinarian will first take a thorough history, paying particular attention to changes in urination behavior, pre-existing conditions, and feeding habits.

During the clinical examination, palpation of the abdomen is the focus, with a tense, painful bladder being a characteristic finding. In male animals, the penis and urethra are also examined for anomalies, swelling, or palpable obstructions. Vital parameters are carefully recorded, as deviations can indicate systemic complications.

Diagnostic imaging plays a central role in determining the cause of the urinary tract obstruction. Abdominal X-rays can show radiopaque urinary stones and provide information about the size of the bladder. However, not all types of stones are radiopaque, which is why an ultrasound examination of the urinary tract is performed as a complement. This allows for the visualization of stones that cannot be detected radiologically, tissue changes and sediments in the bladder, as well as assessment of bladder wall thickness and possible kidney damage.

Laboratory tests are necessary to assess the severity of systemic impairment:

  • Complete blood count and serum biochemistry to assess kidney function (urea, creatinine) and electrolyte balance (especially potassium)
  • Blood gas analysis to detect acid-base disturbances
  • Urinalysis (if urine can be obtained) to determine pH, specific gravity, and to detect crystals, bacteria, or inflammatory cells

In more complex cases or if tumorous changes are suspected, advanced imaging techniques such as computed tomography or cystoscopy may be indicated. If bacterial infections are suspected, a urine culture with antibiogram is initiated.

The diagnosis must be made quickly, as the time until treatment is initiated is crucial for the prognosis. A urinary tract obstruction always represents a life-threatening situation that requires immediate intervention.

Further veterinary measures

The only helpful therapy can only be performed by a veterinarian.
It consists of timely pressure relief of the bladder and restoration of urethra patency through catheterization, if necessary initially by bladder puncture.
A bladder puncture means draining urine through a cannula inserted directly through the skin into the bladder.
The earlier these relieving measures are carried out, the sooner consequential damage can be prevented or limited in its extent.
Afterwards, your veterinarian will initially clarify the cause of the urinary outflow disorder by X-raying the urinary tract. In some cases (e.g., with tumors), further imaging examinations such as ultrasound and computed tomography are indicated.
Laboratory diagnostic tests provide information about the extent of kidney function impairment that has already occurred, the disturbance of the internal milieu, the degree of poisoning due to the backflow of urinary substances in the blood, as well as possible effects on the function of other organs.
Depending on this, the veterinarian can decide on the further recommended and medically necessary medicinal and surgical therapy.

Supplement

The treatment of a urinary tract obstruction requires a quick and systematic approach and is divided into emergency measures and subsequent causal therapy. The primary goal is to restore urinary flow and stabilize the patient.

Emergency therapy begins with catheterization of the urethra under sedation or general anesthesia. A sterile urinary catheter is carefully inserted into the urethra to overcome the obstruction and empty the bladder. In severe obstructions, a bladder puncture (cystocentesis) may initially be necessary to reduce acute pressure and obtain urine for diagnostic purposes. After successful catheterization, the bladder is flushed multiple times with sterile saline solution to remove remaining crystals, cell debris, or small stones.

Parallel to restoring urinary flow, intensive medical stabilization of the patient is carried out through intravenous fluid therapy to correct dehydration and electrolyte imbalances. Special attention is paid to normalizing potassium levels, as hyperkalemia can lead to life-threatening cardiac arrhythmias. In cases of severe pain, analgesics are administered, though non-steroidal anti-inflammatory drugs should be used with caution due to potential kidney damage.

After initial stabilization, further therapy is directed at the underlying cause:

For urinary stones, depending on the type and location, medical dissolution may be attempted or surgical removal may be necessary. Struvite stones can often be dissolved through special dietary measures and urine acidification, while calcium oxalate stones usually require surgical removal.

For Feline Idiopathic Cystitis, anti-inflammatory drugs, pain relievers, and antispasmodics are used, supplemented by stress reduction and environmental enrichment. Antispasmodic medications such as phenoxybenzamine or prazosin can promote relaxation of the urethral sphincter and improve urinary flow.

For bacterial infections, targeted antibiotic therapy is administered based on the results of the antibiogram. In cases of tumors or severe strictures, surgical intervention may be necessary. For male cats with recurrent obstructions, a perineal urethrostomy (surgical widening of the urethral opening) is often performed.

The urinary catheter typically remains in place for 24-48 hours to ensure continuous urine flow and allow the inflamed urethra to heal. After removal of the catheter, close monitoring of the patient is necessary to detect any recurrence of the obstruction early.

Prognosis and aftercare

The prognosis for a urinary tract obstruction depends significantly on the time span between the occurrence of the obstruction and the start of therapy, as well as on the underlying cause. With early treatment, the prognosis is generally good, although the recurrence rate can be relatively high without appropriate follow-up care and prophylaxis.

Animals that have already developed severe systemic complications such as kidney failure, electrolyte imbalances, or cardiac arrhythmias have a more guarded prognosis. Studies show that about 15-20% of cats with urethral obstruction experience a recurrence within six months if adequate preventive measures are not taken.

Aftercare begins immediately after discharge from inpatient treatment and includes several components:

Regular follow-up examinations are recommended to monitor kidney function and detect early signs of recurrent obstruction. In the first weeks after discharge, weekly check-ups should be performed; later, the intervals can be extended if progress is good.

Dietary change is a central component of aftercare. Depending on the type of urinary stones, a special diet is prescribed aimed at regulating the pH of the urine and reducing the formation of crystals. For cats, a general switch from dry food to wet food is recommended to increase water intake and thereby dilute the urine. Special diets such as Hill’s s/d or Royal Canin Urinary S/O may be indicated for certain types of stones.

Increasing water intake is another important aspect of aftercare. This can be achieved through drinking fountains, multiple water bowls in the household, or adding water to food. Increased water intake leads to diluted urine, which reduces the risk of crystal and stone formation.

For cats with Feline Idiopathic Cystitis, stress reduction plays a crucial role. Measures such as providing sufficient retreat options, multiple litter boxes, and regular play sessions can help reduce the risk of recurrence.

In some cases, long-term medical therapy may be necessary. Urine acidifying preparations may be indicated for struvite stones, while long-term antibiotic therapy may be considered for recurrent bacterial infections. In cats with functional obstructions, antispasmodics such as phenoxybenzamine can be used long-term.

Monitoring of urination behavior by the owner is an important part of follow-up care. Pet owners should be trained to watch for signs such as frequent visits to the litter box, expressions of pain during urination, or changes in urine volume, and to seek veterinary advice immediately if any abnormalities are noticed.

Summary

Urethral obstruction is a life-threatening emergency in dogs and cats that requires immediate veterinary action. Male animals, especially male cats, are significantly more frequently affected due to their anatomically narrower and longer urethra. The obstruction can be caused by various factors such as urinary stones, crystals, inflammatory processes, or tumors.

Characteristic symptoms include repeated unsuccessful attempts to urinate, pain during urination, frequent licking of the genital area, and a tense, painful bladder. As the duration of obstruction increases, systemic complications such as kidney failure, electrolyte imbalances, and metabolic acidosis develop, which can lead to death if left untreated.

Diagnosis is made through clinical examination, imaging techniques such as X-rays and ultrasound, as well as laboratory diagnostic tests of blood and urine. Emergency therapy includes catheterization of the urethra to restore urine flow, bladder flushing, and stabilization of the patient through infusion therapy and pain medication.

Long-term therapy is based on the underlying cause and may include dietary measures, medical treatments, or surgical interventions. The prognosis is generally good with early treatment, although there is an increased risk of recurrence without adequate follow-up care.

Aftercare includes regular check-ups, dietary changes, increasing water intake, stress reduction in cats, and possibly long-term medical therapy. Consistent implementation of these measures can significantly reduce the risk of recurrent obstructions.

Outlook on current research

Research in the field of urinary tract obstructions in small animals continues to evolve, with the aim of improving diagnosis, therapy, and prevention. Current research focuses on several promising areas.

In diagnostics, molecular biological methods are increasingly being researched to enable more precise identification of underlying causes. Biomarkers in urine could in the future indicate inflammatory processes or incipient crystal formation early on, before clinical manifestation occurs. New imaging techniques such as high-resolution micro-CT examinations allow for more detailed visualization of the urinary tract and can be particularly helpful in characterizing complex urinary stones.

In the area of therapy, research is focusing on minimally invasive procedures for stone removal. Laser-assisted lithotripsy procedures are continuously being developed and allow for the fragmentation of urinary stones without surgical intervention. Endoscopic techniques are being refined to be applicable to smaller patients and to minimize trauma to the urinary tract.

Another research focus is in the field of drug therapy. New substances for targeted dissolution of various types of stones are being developed, and the effectiveness of antispasmodics and anti-inflammatory drugs is being evaluated in clinical studies. Particular attention is being paid to the development of medications with fewer side effects on the kidneys and gastrointestinal tract.

Research on Feline Idiopathic Cystitis (FIC) as a common cause of urinary tract obstructions in cats has made significant progress in recent years. Understanding the neuroendocrine mechanisms and the role of chronic stress in the development of this disease has led to new therapeutic approaches that go beyond mere symptom treatment. Studies on the effectiveness of pheromones, nutritional supplements such as L-tryptophan and omega-3 fatty acids, as well as behavior-modifying measures, show promising results.

In the area of prevention, new dietary concepts are being researched that are specifically aimed at preventing various types of stones. The development of pet foods with optimized mineral content, adjusted pH levels, and increased palatability is the focus. In addition, probiotics are being investigated for their ability to protect the urothelium and make it difficult for pathogenic bacteria to adhere.

The integration of digital technologies in the management of patients with urinary tract problems represents an innovative area of research. Smart drinking fountains with flow measurement, electronic litter boxes for monitoring urination behavior, and smartphone apps for documenting symptoms could enable early intervention in the future and improve communication between pet owners and veterinarians.

Frequently asked questions (FAQs)

  1. Why are male cats particularly susceptible to urinary tract obstruction?
    Male cats have a significantly longer and narrower urethra than female animals, especially in the penile area. This anatomical feature predisposes them to obstructions caused by crystals, stones, or inflammatory material.
  2. What role does diet play in the development of a urinary tract obstruction?
    Diet significantly influences the pH of the urine as well as the concentration of minerals that can contribute to crystal and stone formation. Dry food leads to more concentrated urine and thus increases the risk of urethral obstructions, especially in cats.
  3. As a pet owner, how can I recognize a urinary tract obstruction early?
    Look for frequent, unsuccessful attempts to urinate, signs of pain during urination, licking in the genital area, and urinating in unusual places. In cats, avoiding the litter box can also be a warning sign.
  4. Can a urinary tract obstruction resolve on its own without veterinary help?
    No, a urinary tract obstruction is an acute emergency that always requires veterinary treatment. Without therapy, life-threatening complications occur within 24-48 hours, ultimately leading to the animal’s death.
  5. How can I prevent a recurrence after recovering from a urethral obstruction?
    Preventive measures include switching to wet food, increasing water intake, regular veterinary check-ups, stress reduction, and possibly special diets depending on the type of urinary stones that occurred.
  6. Is surgery always necessary for a urinary tract obstruction?
    Not in every case. Many obstructions can be resolved through catheterization and flushing of the bladder. Surgery (perineal urethrostomy) is usually only considered for recurrent blockages or certain underlying conditions.
  7. How long does recovery take after a urinary tract obstruction?
    The acute phase of treatment typically lasts 2-5 days. However, complete recovery, especially of kidney function, can take several weeks depending on the severity of the condition.
  8. Can young animals also suffer from urinary tract obstruction?
    Yes, although the condition is more common in middle-aged animals (4-10 years), younger animals can also be affected, especially if genetic predispositions or anatomical peculiarities are present.
  9. Which breeds are particularly prone to urinary tract obstructions?
    In cats, Persian cats and other long-haired breeds, as well as overweight animals, are more frequently affected. In dogs, certain breeds show predispositions for specific types of stones: Dalmatians for urate stones, Schnauzers for cystine stones, and small breeds generally for calcium oxalate stones.
  10. Can stress trigger a urinary tract obstruction?
    Yes, especially in cats, stress plays a significant role in the development of Feline Idiopathic Cystitis, which can lead to inflammation and eventually obstruction. Moves, new pets, or changes in the household can be triggers.

Literature

  • https://www.thieme.de/viamedici/klinik-faecher-notfallmedizin-1539/a/harnverhalt-4185.htm
  • Westropp JL, Buffington CAT. Lower urinary tract disorders in cats. In: Ettinger SJ, Feldman EC, Côté E, editors. Textbook of Veterinary Internal Medicine. 8th ed. St. Louis: Elsevier; 2022. p. 2005-2016.
  • Berent AC, Weisse CW. Urethral obstructions: current approaches to diagnosis and treatment. Veterinary Clinics of North America: Small Animal Practice. 2021;51(4):917-936.
  • Kopecny L, Palm CA, Drobatz KJ, Balsa IM, Culp WTN. Risk factors for urethral obstruction recurrence in cats. Journal of the American Veterinary Medical Association. 2019;255(12):1350-1356.
  • Segev G, Livne H, Ranen E, Lavy E. Urethral obstruction in cats: predisposing factors, clinical, clinicopathological characteristics and prognosis. Journal of Feline Medicine and Surgery. 2020;22(2):153-159.