{"id":35995,"date":"2024-06-05T12:29:04","date_gmt":"2024-06-05T10:29:04","guid":{"rendered":"https:\/\/petsvetcheck.de\/krankheiten-und-stoerungen\/hund\/hyperostosis-cutis-ehlers-danlos-syndrom-kutane-asthenie\/"},"modified":"2026-08-21T08:18:14","modified_gmt":"2026-08-21T06:18:14","slug":"hyperostosis-cutis-ehlers-danlos-syndrome-cutaneous-asthenia","status":"publish","type":"krankheit","link":"https:\/\/petsvetcheck.de\/en\/diseases-and-disorders\/dog\/hyperostosis-cutis-ehlers-danlos-syndrome-cutaneous-asthenia\/","title":{"rendered":"Inherited Collagen Defect in the Connective Tissue of Dogs (Ehlers-Danlos Syndrome, Cutaneous Asthenia)"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","krankheitsort":[138],"haufigkeit":[135],"organsystem_krankheiten":[208],"class_list":["post-35995","krankheit","type-krankheit","status-publish","hentry","krankheitsort-haut-fell-en","haufigkeit-c-en","organsystem_krankheiten-skin","entry"],"acf":{"synonyme":"","synonyme_en":"Cutaneous Hyperextensibility","titel_en":"Ehlers-Danlos Syndrome (EDS)","weitere_suchbegriffe":"","triage":"yellow","triage_begruendung":"Very thin, tearable skin; management and protection, promptly treat deep tears.","definition":"Ehlers-Danlos syndrome or cutaneous asthenia in dogs is a rare genetic disorder characterized by an abnormal collagen structure in the connective tissue of the skin, leading to increased skin elasticity and fragility.","ursachen":"Ehlers-Danlos syndrome in dogs is a genetic disorder caused by defects in collagen synthesis. Collagen is an important structural protein that ensures the strength and elasticity of the skin and other tissues. In dogs with this disorder, the collagen is abnormally structured, leading to a weakness of the connective tissue.\n\nThe genetic basis of the condition can vary, but often an autosomal recessive inheritance pattern is responsible. This means that both parents must be carriers of the defective gene for a puppy to be affected. In some breeds, it can also be inherited in an autosomal dominant manner, meaning that only one parent needs to pass on the defective gene.\n\nThere are different types of Ehlers-Danlos syndrome, caused by various genetic mutations. Affected breeds include Irish Setters, Boxers, Beagles, and Poodles, among others. Each breed can show different clinical manifestations, depending on the type of collagen deficiency.","auswahl_symptome_rot":[34271,34156,34293,34304,34086,33896,33685],"auswahl_symptome_blau":[34209],"auswahl_symptome_grun":"","erganzungen_zu_symptomen":"The symptoms of cutaneous asthenia in dogs are primarily limited to the skin. Affected dogs show unusually stretchable and fragile skin that can be easily injured. The skin tends to split on its own or tear with minor trauma, leading to bleeding wounds.\n\nAdditional symptoms can include scar tissue formation, skin infections due to increased susceptibility to wounds, and hematomas (bruises). In some dogs, joint problems may also occur, as collagen plays a role there as well.\n\nIn more severe cases, internal organs may also be affected. However, this is rare and tends to occur in advanced stages of the disease. The symptoms can vary in intensity, depending on the severity of the genetic mutation and the affected breed.","zusammenfassung":"Ehlers-Danlos syndrome (EDS) in dogs is a genetic disorder caused by defects in collagen synthesis. Collagen is crucial for the strength and elasticity of the skin and other tissues. In dogs with EDS, the collagen is abnormal, leading to a weakening of the connective tissue. Inheritance is usually autosomal recessive, meaning that both parents must be carriers of the defective gene. However, some breeds may also exhibit autosomal dominant inheritance. Affected dog breeds include Irish Setters, Boxers, Beagles, and Poodles. Symptoms include loose skin, skin wrinkling, easy injury to the skin, and loose joints. Diagnosis is made through clinical examinations, skin biopsies, and genetic tests. There is no cure, so treatment focuses on managing symptoms and avoiding injuries. Wounds must be carefully treated to prevent infections. Preventive measures include breeding controls and avoiding injury risks. Research focuses on genetic causes, diagnostic tests, and potential treatments. The prognosis varies depending on the severity of the disorder, with quality of life being significantly impaired in more severe forms. An interdisciplinary research approach aims to lead to better diagnostic and treatment options in the future.","diagnose":"The diagnosis of Hyperostosis cutis, or Ehlers-Danlos syndrome, is usually made through a combination of clinical examination and specific tests. The veterinarian will check skin elasticity and strength by lifting the skin and examining how far it stretches and how quickly it returns to its original shape.\n\nA biopsy of the skin can also be performed to examine the structure of the collagen under the microscope. This examination can provide information on whether the collagen is abnormal. In some cases, genetic tests can be performed to identify the specific mutation, especially in breeds that are predisposed to the disorder.\n\nAdditionally, blood tests can be performed to rule out other possible causes of skin problems. It is important to establish an accurate diagnosis in order to develop an appropriate treatment strategy.","behandlung":"There is currently no cure for Ehlers-Danlos syndrome in dogs, so treatment focuses on managing symptoms and preventing injuries. Affected dogs should be kept in a safe environment to minimize the risk of skin injuries.\n\nWounds must be carefully monitored and treated to prevent infections. This may include the application of antiseptic solutions and, if necessary, antibiotics. In severe injuries, surgical intervention may be required, although healing can be delayed due to the collagen problem.\n\nPain relief and anti-inflammatory medications may be necessary to alleviate discomfort. In some cases, dietary supplementation with vitamin C may be considered, as it plays a role in collagen synthesis, although the effectiveness of this treatment is controversial.","prognose":"The prognosis for dogs with Hyperostosis cutis varies depending on the severity of the disorder. Dogs with mild forms of the disorder can lead a relatively normal life with appropriate management. In more severe forms, however, quality of life can be significantly impaired, as continuous care and protection are required.\n\nA worsening of symptoms can occur over time, especially if injuries are not carefully avoided. Life expectancy may decrease, particularly if internal organs are affected or severe infections occur.","ausblick_auf_aktuelle_forschung":"Current research on Ehlers-Danlos syndrome (EDS) in dogs, particularly cutaneous asthenia, focuses on the genetic basis of the disorder. Scientists are investigating specific genetic mutations responsible for abnormal collagen production. These mutations lead to reduced strength and elasticity of the skin, contributing to the typical symptoms of the disorder. Researchers use modern genetic sequencing technologies to identify and better understand the responsible genes.\n\nAnother area of research is the development of diagnostic tests that enable early and precise diagnosis. This is crucial to provide affected dogs with the right care in a timely manner. Researchers are working on developing non-invasive tests based on the analysis of skin samples or blood to detect genetic markers for EDS.\n\nTherapeutic approaches are also a research focus. Currently, there is no cure for EDS, but researchers are investigating various treatment options to improve the quality of life of affected dogs. These include the development of medications that could influence collagen production, as well as physiotherapeutic measures to support the affected animals.\n\nIn addition to genetic and therapeutic research, scientists are working to deepen the understanding of the clinical manifestations of the disease. This includes examining the different degrees of severity and symptoms that can occur in affected dogs. A better understanding of this variability can help veterinarians develop individually tailored treatment plans.\n\nAn interdisciplinary approach is crucial for progress in EDS research. Veterinarians, geneticists, and biologists work together to investigate the various aspects of the disease and develop effective solutions. This collaborative approach promises to enable groundbreaking discoveries in the future that could significantly improve the understanding and treatment of EDS in dogs.","zusatzlicher_inhalt_im_hauptteil":"Since Ehlers-Danlos syndrome is genetic, prevention focuses primarily on breeding control. Breeders should take care not to breed affected dogs or carriers of the defective gene. Genetic tests can help identify carriers and should be considered in breeds with a known predisposition.\n\nFor affected dogs, it is important to create an environment that minimizes the risk of injury. This may include avoiding sharp or rough surfaces and wearing protective clothing to protect the skin. Regular veterinary monitoring is also important to assess the dog's health status and detect complications early.","haufig_gestellte_fragen_faqs":"
    \n \t
  1. What is Ehlers-Danlos syndrome (EDS) in dogs?<\/b>\nEDS in dogs is a genetic disorder caused by abnormal collagen production. This leads to reduced strength and elasticity of the skin, resulting in typical symptoms such as overly stretchable skin and increased susceptibility to injury.<\/li>\n \t
  2. Which dogs are affected by EDS?<\/b>\nEDS can occur in dogs of any breed, but some breeds such as Beagles, Boxers, and German Shepherds appear to be more frequently affected. It is believed that the disorder is inherited in an autosomal recessive manner, meaning that both parents must be carriers of the defective gene to pass on the disease.<\/li>\n \t
  3. What symptoms occur in dogs with EDS?<\/b>\nThe most common symptoms are overly stretchable skin that can be easily injured, joint problems, and an increased tendency to hematomas. Some dogs may also have problems with the eyes or internal organs, depending on the severity of the disorder.<\/li>\n \t
  4. How is EDS diagnosed in dogs?<\/b>\nDiagnosis is usually based on a combination of clinical symptoms, a thorough physical examination, and genetic tests. Veterinarians may also perform skin biopsies to examine the collagen structure and confirm the diagnosis.<\/li>\n \t
  5. Is there a cure for EDS in dogs?<\/b>\nCurrently, there is no cure for EDS in dogs. Treatment focuses on alleviating symptoms and improving quality of life. This can be achieved through skin protection, pain management, and physiotherapeutic measures.<\/li>\n \t
  6. Can dogs with EDS lead a normal life?<\/b>\nDogs with EDS can lead a relatively normal life with appropriate care and attention. It is important to avoid injuries and take good care of the skin. Regular veterinary checkups help detect and treat complications early.<\/li>\n \t
  7. How can I help my dog with EDS?<\/b>\nTo help your dog with EDS, you should ensure a protective environment that minimizes the risk of injury. Use soft bedding and avoid rough play that could stress the skin. A special diet and care program can also help support skin health.<\/li>\n \t
  8. Is EDS in dogs contagious?<\/b>\nNo, EDS is not contagious. It is a genetic disorder that cannot be transmitted through contact with other animals or humans.<\/li>\n \t
  9. What progress is being made in EDS research?<\/b>\nIn research, progress is being made in identifying the genetic causes of EDS as well as in developing better diagnostic methods. In addition, therapies are being investigated that could alleviate symptoms and improve the quality of life of affected dogs.<\/li>\n \t
  10. Can EDS in dogs be prevented?<\/b>\nSince it is a genetic disorder, EDS cannot be completely prevented. However, breeders can use genetic tests to identify carriers of the defective gene and make targeted breeding decisions to minimize the risk of passing on the disease.<\/li>\n<\/ol>","literaturangaben":"
      \n \t
    • Bullock, G., Jaffey, J. A., Cohn, L. A., Sox, E., Hostnik, E. T., Hutcheson, K. D., Matero, E., Hoffmann, K. S., Johnson, G. S., & Katz, M. L. (2024). Novel COL5A1 variants and associated disease phenotypes in dogs with classical Ehlers\u2013Danlos syndrome. Journal of Veterinary Internal Medicine, 38(5), 2431\u20132443. https:\/\/doi.org\/10.1111\/jvim.17180<\/li>\n \t
    • Bauer, A., Bateman, J. F., Lamand\u00e9, S. R., Hanssen, E., Kirejczyk, S. G. M., Yee, M., Ramiche, A., Jagannathan, V., Welle, M., Leeb, T., & Bateman, F. L. (2019). Identification of two independent COL5A1 variants in dogs with Ehlers\u2013Danlos syndrome. Genes, 10(10), 731. https:\/\/doi.org\/10.3390\/genes10100731<\/li>\n \t
    • Kiener, S., Chevallier, L., Jagannathan, V., Briand, A., Cochet-Faivre, N., Reyes-Gomez, E., & Leeb, T. (2022). A COL5A2 in-frame deletion in a Chihuahua with Ehlers\u2013Danlos syndrome. Genes, 13(5), 934. https:\/\/doi.org\/10.3390\/genes13050934<\/li>\n \t
    • Jaffey, J. A., Bullock, G., Guo, J., Mhlanga-Mutangadura, T., O'Brien, D. P., Coates, J. R., Morrissey, R., Hutchison, R., Donnelly, K. S., Cohn, L. A., Katz, M. L., & Johnson, G. S. (2022). Novel homozygous ADAMTS2 variants and associated disease phenotypes in dogs with dermatosparactic Ehlers\u2013Danlos syndrome. Genes, 13(11), 2158. https:\/\/doi.org\/10.3390\/genes13112158<\/li>\n \t
    • Paciello, O., Lamagna, F., Lamagna, B., & Papparella, S. (2003). Ehlers-Danlos-like syndrome in 2 dogs: Clinical, histologic, and ultrastructural findings. Veterinary Clinical Pathology, 32(1), 13\u201318. https:\/\/doi.org\/10.1111\/j.1939-165X.2003.tb00306.x<\/li>\n \t
    • Bellini, M. H., Schor, N., & Soares, A. M. V. C. (2009). Increased elastic microfibrils and thickening of fibroblastic nuclear lamina in canine cutaneous asthenia. Veterinary Dermatology, 20(2), 139\u2013143. https:\/\/doi.org\/10.1111\/j.1365-3164.2008.00732.x<\/li>\n \t
    • Poulsen, P. H., Flagstad, A., & Basse, A. (1985). Cutaneous asthenia in the dog: A report of two cases. Acta Veterinaria Scandinavica, 26(3), 467\u2013475.<\/li>\n \t
    • Rasch, S. N., Long, A. J., & Conway, J. A. (2017). Surgical and medical treatment of ocular disease in a dog with Ehlers\u2013Danlos syndrome. Clinical Case Reports, 5(7), 1198\u20131203. https:\/\/doi.org\/10.1002\/ccr3.972<\/li>\n<\/ul>","symptome_ausgeblendet":"","erganzungen":"","faq":[{"frage":"1. What is Ehlers-Danlos syndrome (EDS) in dogs?","antwort":"EDS in dogs is a genetic condition caused by abnormal collagen production. This leads to reduced skin strength and elasticity, resulting in typical symptoms such as overly stretchable skin and an increased risk of injury. -"},{"frage":"2. Which dogs are affected by EDS?","antwort":"EDS can occur in dogs of any breed, but some breeds such as Beagles, Boxers, and German Shepherds seem to be affected more often. The condition is thought to be inherited in an autosomal recessive manner, meaning both parents must carry the defective gene to pass the disease on. -"},{"frage":"3. What symptoms occur in dogs with EDS?","antwort":"The most common symptoms are overly stretchable skin that can be injured easily, joint problems, and an increased tendency to develop bruises. Some dogs may also have issues with the eyes or internal organs, depending on the severity of the condition. -"},{"frage":"4. How is EDS diagnosed in dogs?","antwort":"The diagnosis is usually based on a combination of clinical symptoms, a thorough physical examination, and genetic testing. Veterinarians may also perform skin biopsies to examine the collagen structure and confirm the diagnosis. -"},{"frage":"5. Is there a cure for EDS in dogs?","antwort":"There is currently no cure for EDS in dogs. Treatment focuses on relieving symptoms and improving quality of life. This can be achieved through protective measures for the skin, pain management, and physiotherapy. -"},{"frage":"6. Can dogs with EDS lead a normal life?","antwort":"With appropriate care and management, dogs with EDS can live a relatively normal life. It is important to avoid injuries and take good care of the skin. Regular veterinary check-ups help detect and treat complications early. -"},{"frage":"7. How can I help my dog with EDS?","antwort":"To help your dog with EDS, ensure a protective environment that minimizes the risk of injury. Use soft bedding and avoid rough play that could strain the skin. A tailored diet and care program can also help support skin health. -"},{"frage":"8. Is EDS in dogs contagious?","antwort":"No, EDS is not contagious. It is a genetic condition that cannot be transmitted through contact with other animals or people. -"},{"frage":"9. What progress is being made in EDS research?","antwort":"Research is making progress in identifying the genetic causes of EDS and developing better diagnostic methods. In addition, therapies are being explored that could relieve symptoms and improve the quality of life of affected dogs. -"},{"frage":"10. Can EDS in dogs be prevented?","antwort":"Since it is a genetic disorder, EDS cannot be completely prevented. However, breeders can use genetic tests to identify carriers of the defective gene and make informed breeding decisions to minimize the risk of passing on the disease."}],"faq_html":null},"yoast_head":"\nInherited Collagen Defect in the Connective Tissue of Dogs (Ehlers-Danlos Syndrome, Cutaneous Asthenia) in dogs<\/title>\n<meta name=\"description\" content=\"Learn more about Cutaneous Asthenia, also known as Ehlers-Danlos syndrome (EDS), a rare connective tissue disorder in dogs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/petsvetcheck.de\/en\/diseases-and-disorders\/dog\/hyperostosis-cutis-ehlers-danlos-syndrome-cutaneous-asthenia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Inherited Collagen Defect in the Connective Tissue of Dogs (Ehlers-Danlos Syndrome, 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