{"id":35780,"date":"2024-06-05T12:29:25","date_gmt":"2024-06-05T10:29:25","guid":{"rendered":"https:\/\/petsvetcheck.de\/krankheiten-und-stoerungen\/hund\/nicht-ulzerative-keratitis-hornhautentzuendung-des-auges\/"},"modified":"2026-10-15T14:51:32","modified_gmt":"2026-10-15T12:51:32","slug":"non-ulcerative-keratitis-inflammatory-conditions-of-the-cornea","status":"publish","type":"krankheit","link":"https:\/\/petsvetcheck.de\/en\/diseases-and-disorders\/dog\/non-ulcerative-keratitis-inflammatory-conditions-of-the-cornea\/","title":{"rendered":"Inflammation of the Clear Surface of the Eye Without Ulcers in Dogs (Nonulcerative Keratitis)"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","krankheitsort":[141],"haufigkeit":[134],"organsystem_krankheiten":[207],"class_list":["post-35780","krankheit","type-krankheit","status-publish","hentry","krankheitsort-kopf-hals-en","haufigkeit-a-en","organsystem_krankheiten-eyes","entry"],"acf":{"synonyme":"","synonyme_en":"Inflammatory Corneal Disorder","titel_en":"Non-Ulcerative Keratitis","weitere_suchbegriffe":"","triage":"yellow","triage_begruendung":"Corneal inflammation without an ulcer; clarify the cause\u2014drops help prevent vision damage.","definition":"Non-ulcerative keratitis, also known as corneal inflammation, is an inflammatory condition of the cornea of the eye in dogs that occurs without ulcers or open Wounds.","ursachen":"The cornea is the clear, outer layer of the eye that focuses light and allows the dog to see clearly. It consists of several layers: the epithelium, Bowman's membrane, the stroma, Descemet's membrane, and the endothelium. The health of these layers is crucial for maintaining the clarity and functionality of the eye. \n\nNon-ulcerative keratitis is characterized by inflammation of the corneal layers, while the epithelium remains intact. The inflammation can be triggered by various factors, including immune responses, physical irritation, and genetic predispositions. \n\nOne of the most common causes of non-ulcerative keratitis is keratitis sicca, also known as \u201cdry eye,\u201d a condition in which the tear glands do not produce enough tear fluid to adequately lubricate the eye. This leads to chronic irritation and inflammation of the cornea. \n\nGenetic predisposition also plays a significant role, as certain dog breeds, such as the German Shepherd, Dachshund, and Cocker Spaniel, are more commonly affected. In these breeds, the disease can be triggered by hereditary factors or an abnormal immune response. ","auswahl_symptome_rot":[34068,33835,33846,33372,33514,33149,33534,34085,33841],"auswahl_symptome_blau":[33158,34064],"auswahl_symptome_grun":[33473,33134],"erganzungen_zu_symptomen":"Some of the most common symptoms of non-ulcerative keratitis include redness and cloudiness of the cornea, which often appears as a milky or bluish haze. This can impair the dog\u2019s vision. \n\nAnother notable symptom is frequent blinking or closing of the affected eye, as the inflammation is often associated with Pain or discomfort. The dog may also frequently rub its eye with its paw, which increases the risk of an additional infection or further injury. \n\nIn some cases, increased tearing or mucus discharge may also occur as the eye tries to fight the inflammation. The conjunctiva, the tissue that covers the eye and the inside of the eyelids, may also be reddened or swollen. ","zusammenfassung":"Non-ulcerative keratitis is an inflammatory eye disease in dogs in which the corneal layers are affected without damage to the epithelium. The inflammation can be triggered by immune responses, physical irritation, or genetic factors. A common cause is \u201cdry eye,\u201d in which the tear glands do not produce enough tear fluid. Certain dog breeds such as the German Shepherd, Dachshund, and Cocker Spaniel are particularly susceptible. Symptoms include watery or mucous eye discharge, reddened eyes, corneal cloudiness, and sensitivity to light. Diagnosis is made through a thorough eye examination, including Schirmer tear tests and fluorescein staining. The disease is treated with anti-inflammatory eye drops, tear replacement therapies, and in severe cases, systemic medications. The prognosis is often good with timely treatment, but chronic cases can lead to permanent Visual disturbances. Preventive measures include regular eye examinations, good eye hygiene, and avoiding irritants. Researchers are investigating genetic and immunological factors as well as new therapy approaches to better understand and treat the disease. The role of environmental factors such as UV radiation is also being studied to develop better prevention strategies. ","diagnose":"Diagnosis of non-ulcerative keratitis usually begins with a thorough clinical examination of the eye by a veterinarian. This includes using an ophthalmoscope to examine the cornea for signs of inflammation, cloudiness, or other abnormalities. \n\nA Schirmer tear test can be performed to measure tear production and rule out or confirm keratoconjunctivitis sicca. In this test, a special paper is placed over the lower eyelid to measure the amount of tears produced. \n\nAnother important diagnostic test is fluorescein staining, in which a dye is placed in the eye to rule out injuries or ulcers of the cornea. Since this is a non-ulcerative form of keratitis, no green staining of the cornea should be visible. \n\nIn some cases, cytology or a biopsy of the cornea may be required to determine the underlying cause of the inflammation. These procedures help identify inflammatory cells or infectious agents. ","behandlung":"Treatment of non-ulcerative keratitis aims to reduce inflammation and maintain corneal health. In many cases, anti-inflammatory eye drops or ointments are prescribed to relieve Swelling and Pain. \n\nIn dogs with keratitis sicca, tear replacement therapy or the use of medications that stimulate tear production is often considered. Cyclosporine A or tacrolimus are commonly used medications in these cases. \n\nIn more severe cases, or when an immunological cause is suspected, systemic medications such as corticosteroids may be used to control the inflammation. However, these should be used with caution, as they can have side effects. \n\nRegular monitoring of the eye is crucial to assess treatment success and make adjustments as needed. In some cases, surgery may be required, especially for structural anomalies of the eyelids or tear glands. ","prognose":"The prognosis for dogs with non-ulcerative keratitis varies depending on the cause and severity of the condition. With early diagnosis and appropriate treatment, the prognosis is generally good, and many dogs can achieve a normal quality of life. \n\nHowever, chronic cases or those that do not respond to treatment may lead to permanent Visual disturbances. It is important to follow the veterinarian's treatment plan closely and have regular follow-up examinations to monitor the condition. \n\nDogs that are genetically predisposed may require lifelong management and regular care to prevent the disease from progressing and to preserve eye function.","ausblick_auf_aktuelle_forschung":"Non-ulcerative keratitis, also known as chronic superficial keratitis or pannus, is an inflammatory eye disease that occurs mainly in certain dog breeds, such as the German Shepherd. Recently, research has made significant progress in identifying genetic and immunological factors that contribute to this condition. One of the key findings is the role of the body\u2019s own immune response, which is influenced by environmental factors and genetic predispositions. Researchers are increasingly investigating specific genetic markers that predispose dogs to this disease, which could influence future breeding programs. \n\nAnother exciting area of research is the development of new therapy approaches aimed at modulating the immune system. While conventional treatments such as topical corticosteroids and immunosuppressants are widely used, efforts are underway to develop more targeted therapies with fewer side effects. These include novel drugs that block specific inflammatory pathways, as well as trials of gene therapies aimed at correcting faulty genetic information. \n\nIn addition, ongoing studies are looking at the role of environmental factors such as UV radiation in the development and progression of non-ulcerative keratitis. It is suspected that UV light could amplify the immune response in susceptible dogs, which could lead to worsening symptoms. Researchers are therefore investigating the effectiveness of UV protection measures, such as special dog goggles or applying UV-blocking substances to the eyes as a prevention strategy. \n\nAnother line of research focuses on improving diagnosis of the disease. Advances in imaging technology, such as confocal microscopy, allow veterinarians to create detailed images of the cornea to better assess the severity of the inflammation and monitor the course of treatment more accurately. These technologies could also help shorten diagnosis times and improve treatment outcomes. \n\nIn summary, research into non-ulcerative keratitis in dogs is a dynamic field that seeks to better understand the genetic, immunological, and environmental factors behind this complex condition. These findings could not only lead to better treatment strategies, but also contribute to prevention and possibly even the eradication of the disease in susceptible populations. ","zusatzlicher_inhalt_im_hauptteil":"Prevention of non-ulcerative keratitis requires regular eye examinations, especially in dog breeds that are prone to it. Early detection and treatment of eye diseases can help reduce the risk of keratitis. \n\nGood eye hygiene, including regular cleaning of the eyes and avoiding irritants, can also help minimize the risk of Inflammatory conditions. In dogs with known allergies or eye diseases, regular use of eye drops or ointments may be recommended for prevention. \n\nIt\u2019s important for dog owners to watch for signs of eye problems, such as excessive blinking, redness, tearing, or cloudiness, and to seek veterinary advice promptly if needed.","haufig_gestellte_fragen_faqs":"
    \n \t
  1. What is non-ulcerative keratitis in dogs?<\/b> Non-ulcerative keratitis is a chronic inflammation of the cornea of the eye that does not lead to the formation of ulcers. It often occurs in certain breeds and can be caused by a combination of genetic and environmental factors. <\/li>\n \t
  2. What symptoms does a dog with non-ulcerative keratitis show?<\/b> Typical symptoms include Redness of the eyes, cloudiness of the cornea, increased blinking or squinting, and possibly eye discharge. In advanced cases, pigmentation of the cornea may also occur. <\/li>\n \t
  3. Which breeds are most commonly affected?<\/b> German Shepherds are particularly commonly affected, but other breeds such as Greyhounds and Border Collies can also be susceptible. It is believed that genetic predisposition plays a major role in susceptibility to this condition. <\/li>\n \t
  4. How is the disease diagnosed?<\/b> Diagnosis is usually made through a thorough eye examination by a veterinarian. The cornea and surrounding structures are examined for signs of inflammation and pigmentation. In some cases, additional tests such as measuring intraocular pressure or special imaging techniques may be required. <\/li>\n \t
  5. What treatment options are there?<\/b> Treatment usually includes the use of topical corticosteroids or immunosuppressants to reduce inflammation. In severe cases, surgical procedures may be required. Treatment aims to control symptoms and slow the progression of the disease. <\/li>\n \t
  6. Can non-ulcerative keratitis be cured?<\/b> A complete cure is rare because it is a chronic condition. The therapy aims to alleviate symptoms and prevent the progression of the disease. With the right treatment, however, most dogs can live a normal life. <\/li>\n \t
  7. Are there preventive measures?<\/b> Since UV radiation can play a role in worsening symptoms, it is recommended to protect affected dogs from excessive sun exposure. This can be done by staying in the shade, wearing dog goggles, or using UV-blocking drops. <\/li>\n \t
  8. How does the disease affect the dog's life?<\/b> If left untreated, the disease can lead to significant discomfort and vision loss. However, with the right treatment, the dog's comfort can be improved and the progression of the disease can be slowed down. <\/li>\n \t
  9. Are regular veterinary visits necessary?<\/b> Yes, regular check-ups with the veterinarian are important to monitor the course of the disease and adjust treatment accordingly. This helps avoid complications and maintain the dog\u2019s quality of life. <\/li>\n \t
  10. Is there hope for new treatment methods?<\/b> Ongoing research is promising and could lead to new, more effective treatment methods in the future. Genetic research and the development of new medications, in particular, offer hope for improved therapies for affected dogs. <\/li>\n<\/ol>","literaturangaben":"
      \n \t
    • Bedford, P. G. C., Longstaffe, J. A., & Grierson, I. (1979). Corneal pannus (chronic superficial keratitis) in the German shepherd dog. Journal of Small Animal Practice, 20(1), 41\u201356. https:\/\/doi.org\/10.1111\/j.1748-5827.1979.tb07019.x<\/li>\n \t
    • Williams, D. L. (1999). Histological and immunohistochemical evaluation of canine chronic superficial keratitis. Research in Veterinary Science, 67(2), 191\u2013195. https:\/\/doi.org\/10.1053\/rvsc.1999.0329<\/li>\n \t
    • Drahovsk\u00e1, Z., Balicki, I., Trbolov\u00e1, A., Mihalov\u00e1, M., & Holi\u010dkov\u00e1, M. (2014). A retrospective study of the occurrence of chronic superficial keratitis in 308 German Shepherd dogs: 1999\u20132010. Polish Journal of Veterinary Sciences, 17(3), 543\u2013546. https:\/\/doi.org\/10.2478\/pjvs-2014-0082<\/li>\n \t
    • Karamatic, S., Bartl, J., Kova\u010d, K., Samard\u017eija, M., Capak, H., Galov, A., & Curik, I. (2022). Genome-wide association analysis for chronic superficial keratitis in dogs. Genes, 13(8), Article 1328. https:\/\/doi.org\/10.3390\/genes13081328<\/li>\n \t
    • Maini, S., Everson, R., Dawson, C., Chang, Y. M., Hartley, C., & Sanchez, R. F. (2019). Pigmentary keratitis in pugs in the United Kingdom: Prevalence and associated features. BMC Veterinary Research, 15, Article 384. https:\/\/doi.org\/10.1186\/s12917-019-2127-y<\/li>\n \t
    • Sarmiento Quintana, D., Su\u00e1rez, M. L., Gonz\u00e1lez, M. A., & Esteban, J. (2024). Ocular surface characteristics in pugs with pigmentary keratitis. Animals, 14(4), Article 580. https:\/\/doi.org\/10.3390\/ani14040580<\/li>\n \t
    • Kim, H., Jeong, Y., Lee, E., Seo, K., & Kang, S. (2023). Treatment of immune-mediated keratitis (IMMK) in dogs with immunosuppressants observed with spectral domain optical coherence tomography (SD-OCT). Journal of Veterinary Science, 24(5), Article e66. https:\/\/doi.org\/10.4142\/jvs.23059<\/li>\n<\/ul>","symptome_ausgeblendet":"","erganzungen":"","faq":[{"frage":"1. What is non-ulcerative keratitis in dogs?","antwort":"Non-ulcerative keratitis is a chronic inflammation of the cornea of the eye that does not lead to the formation of ulcers. It often occurs in certain breeds and can be caused by a combination of genetic and environmental factors."},{"frage":"2. What symptoms does a dog with non-ulcerative keratitis show?","antwort":"Typical symptoms include Redness of the eyes, corneal clouding, increased blinking or squinting, and possibly eye discharge. In advanced cases, corneal pigmentation may also occur."},{"frage":"3. Which breeds are most commonly affected?","antwort":"German Shepherds are particularly affected, but other breeds such as Greyhounds and Border Collies can also be susceptible. It is believed that genetic predisposition plays a major role in susceptibility to this condition."},{"frage":"4. How is the disease diagnosed?","antwort":"diagnosis is usually made through a thorough eye examination by a veterinarian. The cornea and surrounding structures are examined for signs of inflammation and pigmentation. In some cases, additional tests such as measuring intraocular pressure or special imaging techniques may be required."},{"frage":"5. What treatment options are available?","antwort":"Treatment usually involves the application of topical corticosteroids or immunosuppressants to reduce inflammation. In severe cases, surgical intervention may be necessary. The treatment aims to control symptoms and slow the progression of the disease."},{"frage":"6. Can non-ulcerative keratitis be cured?","antwort":"Complete healing is rare, as it is a chronic condition. Treatment aims to alleviate symptoms and prevent the progression of the disease. However, with proper treatment, most dogs can lead a normal life."},{"frage":"7. Are there any preventive measures?","antwort":"Since UV radiation can play a role in worsening symptoms, it is recommended to protect affected dogs from excessive sun exposure. This can be done by staying in the shade, wearing dog goggles, or using UV-blocking drops."},{"frage":"8. How does the disease affect the dog\u2019s life?","antwort":"If left untreated, the disease can lead to significant discomfort and vision loss. However, with proper treatment, the dog's comfort can be improved and the progression of the disease slowed."},{"frage":"9. Are regular vet visits necessary?","antwort":"Yes, regular check-ups with the veterinarian are important to monitor the course of the disease and adjust treatment accordingly. This helps to avoid complications and maintain the dog's quality of life."},{"frage":"10. Is there hope for new treatment methods?","antwort":"Ongoing research is promising and could lead to new, more effective treatment methods in the future. Genetic research and the development of new medications, in particular, offer hope for improved therapies for affected dogs. 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