{"id":35677,"date":"2024-06-05T12:29:43","date_gmt":"2024-06-05T10:29:43","guid":{"rendered":"https:\/\/petsvetcheck.de\/krankheiten-und-stoerungen\/hund\/sterile-granulomatoese-dermatitis-oder-lymphadenitis-bei-welpen-canine-juvenile-zellulitis\/"},"modified":"2026-08-13T09:57:20","modified_gmt":"2026-08-13T07:57:20","slug":"sterile-granulomatous-dermatitis-or-lymphadenitis-in-puppies-canine-juvenile-cellulitis","status":"publish","type":"krankheit","link":"https:\/\/petsvetcheck.de\/en\/diseases-and-disorders\/dog\/sterile-granulomatous-dermatitis-or-lymphadenitis-in-puppies-canine-juvenile-cellulitis\/","title":{"rendered":"Sterile Nodular Inflammation of the Skin and Lymph Nodes in Puppies (Sterile Granulomatous Dermatitis or Lymphadenitis)"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","krankheitsort":[143],"haufigkeit":[134],"organsystem_krankheiten":[208],"class_list":["post-35677","krankheit","type-krankheit","status-publish","hentry","krankheitsort-general-whole-body","haufigkeit-a-en","organsystem_krankheiten-skin","entry"],"acf":{"synonyme":"Juvenile Cellulitis, Juvenile Cellulitis","synonyme_en":"Puppy Strangles","titel_en":"Sterile Juvenile Cellulitis","weitere_suchbegriffe":"","triage":"orange","triage_begruendung":"Puppies with swollen face and pustules; early cortisone prevents scarring.","definition":"Canine juvenile cellulitis, also known as sterile granulomatous dermatitis or lymphadenitis in puppies, is a rare inflammatory disease that primarily affects young dogs and is characterized by swelling in the face and lymph nodes as well as skin changes.","ursachen":"Canine juvenile cellulitis is considered an immune-mediated disease, meaning the dog's immune system mistakenly attacks the body's own tissue. This condition typically occurs in dogs between three and four months of age, but in rare cases can also affect older dogs. \n\nThe exact cause of the disease is not fully understood; however, it is suspected that genetic factors play a role. Certain breeds appear to be more frequently affected, including Golden Retrievers, Labrador Retrievers, Dachshunds, Pointers, and Gordon Setters. It is suspected that a genetic predisposition in conjunction with a triggering event, such as a vaccination or stress, can trigger the condition. \n\nScientific studies suggest that the disease may be caused by disrupted immune regulation, in which the immune system overreacts and triggers inflammatory processes that lead to the characteristic symptoms. However, it is not an infectious disease and is not contagious to other dogs or humans. ","auswahl_symptome_rot":[33447,33978,33527,33677,33487,34178,33893],"auswahl_symptome_blau":[34011,33227,33617,33681,33826,33457,33810,33709,45259],"auswahl_symptome_grun":[33804,33832,33601],"erganzungen_zu_symptomen":"Symptoms of canine juvenile cellulitis typically appear suddenly and can worsen within a few days. The most striking symptom is swelling in the face, particularly around the eyes, lips, and ears. These swellings can develop into purulent skin lesions that can be painful. \n\nIn addition to the swelling, affected puppies may exhibit fever, lethargy, and reduced food intake. The regional lymph nodes, particularly those in the neck, are often enlarged and palpable. In some cases, other body parts, such as the paws, may also be affected. \n\nThe skin lesions may become crusty and heal, but can also leave scars. The overall health of the affected puppy can be significantly impaired by the disease if not treated promptly. ","zusammenfassung":"Canine juvenile cellulitis is an immune-mediated disease in dogs in which the immune system mistakenly attacks the body's own tissue. It typically occurs in puppies between three and four months of age and may affect certain breeds such as Golden Retrievers and Labrador Retrievers more frequently. The exact cause is unknown, but genetic factors and stress may play a role. Symptoms include fever, facial swelling, enlarged lymph nodes, and skin lesions, mainly in the head area. Diagnosis is made through clinical examination and tests such as skin biopsies to rule out other diseases. Treatment focuses on suppressing the immune response, primarily through corticosteroids, and possibly antibiotics to prevent secondary infections. The prognosis is good when the disease is treated early; however, scars may remain. Prevention is difficult since the causes are not fully understood; nevertheless, stress-free environments and tailored vaccination schedules can be helpful. Research focuses on genetic and immunological foundations to develop preventive measures and new treatment methods with fewer side effects. Environmental factors such as stress and diet are also being investigated to minimize disease risk. Research offers hope for better protection and treatment options for future generations of dogs. ","diagnose":"The diagnosis of canine juvenile cellulitis is based on a combination of clinical examination, medical history, and supportive diagnostic tests. Since the symptoms of the disease are characteristic, an experienced veterinarian can often make a presumptive diagnosis based on clinical findings. \n\nTo confirm the diagnosis, skin biopsies may be performed. Histopathological examination of the skin samples typically shows granulomatous inflammation with an accumulation of certain immune cells, indicating the immune-mediated nature of the disease. Additionally, blood tests may be performed to rule out other possible causes of the symptoms. \n\nAnother important aspect of diagnosis is ruling out other diseases with similar symptoms, such as bacterial or fungal infections, which can also cause skin changes and lymph node swelling. In some cases, culture of skin samples may be helpful to rule out the presence of pathogenic microorganisms. ","behandlung":"Treatment of canine juvenile cellulitis primarily involves suppressing the abnormal immune response through the use of medications. Typically, corticosteroids such as prednisone are used to reduce inflammation and calm the immune system. The dosage and duration of treatment depend on the severity of the disease and the dog's response to therapy. \n\nIn some cases, antibiotics may also be administered to prevent or treat secondary bacterial infections of the skin lesions. Additionally, the use of antiseptic solutions or special shampoos can help keep the skin clean and support the healing process. \n\nTreatment should be supervised by a veterinarian, as long-term use of corticosteroids can have side effects. It is important to gradually taper the medication to avoid recurrence of symptoms. ","prognose":"The prognosis for dogs with canine juvenile cellulitis is generally good when the disease is detected early and treated appropriately. Most dogs respond well to corticosteroid therapy and show significant improvement in symptoms within a few days. \n\nIn most cases, the disease heals completely without long-term health problems. However, in some cases, scars may remain on the skin, especially if the skin lesions were severe. \n\nIt is important not to discontinue treatment too early, even if symptoms have disappeared, as premature discontinuation of therapy can lead to relapse. Long-term follow-up examinations with a veterinarian are advisable to monitor the dog's health. ","ausblick_auf_aktuelle_forschung":"Canine juvenile cellulitis, also known as sterile granulomatous dermatitis or lymphadenitis in puppies, is a complex syndrome that is still being intensively researched in veterinary medicine. Current studies focus on better understanding the genetic and immunological basis of this disease. Researchers use genetic markers to identify possible predispositions in certain dog breeds. Advances in genome sequencing technology have made it possible to obtain more accurate data on genetic predispositions. This research aims to develop preventive measures that could reduce the occurrence of the disease. \n\nAnother research focus is on examining the immune response in affected animals. Scientists are investigating the role of autoimmune processes and how the puppies' immune system may overreact and attack their own skin cells. By analyzing immune cells and cytokines, researchers are trying to decipher the mechanisms that lead to the development of the disease. These insights could lead to new therapeutic approaches that specifically modulate the involvement of immune complexes. \n\nFurthermore, there are ongoing studies on the effectiveness of new treatment methods. While corticosteroids currently represent the mainstay of treatment, researchers are investigating alternative medications that have fewer side effects while effectively controlling symptoms. These include immunomodulatory substances that regulate the activity of the immune system, as well as new forms of anti-inflammatory medications. This research could lead to a broader range of treatment options in the future, tailored to the individual needs of affected dogs. \n\nAnother interesting field of research is the role of environmental factors. Researchers are investigating how certain environmental conditions, such as stress, diet, and exposure to certain allergens, could influence the risk of developing the disease. These studies could help develop preventive guidelines for breeders and dog owners to minimize the risk for puppies. \n\nOverall, current research shows promising progress in deciphering the mechanisms and causes of canine juvenile cellulitis. Developments in genetics and immunology, as well as the exploration of new therapeutic approaches, give hope that future generations of dogs can be better protected and treated. ","zusatzlicher_inhalt_im_hauptteil":"Since the exact causes of canine juvenile cellulitis are not fully understood, there are no specific measures for prevention of the disease. However, certain precautions can help reduce the risk of an outbreak. \n\nCareful breeding selection can help minimize the predisposition for the disease in certain breeds. Breeders should avoid breeding dogs that have suffered from the disease in the past or whose parents were affected. \n\nIt is also advisable to raise puppies in a stress-free environment and avoid unnecessary stressors, as stress is suspected as a possible trigger of the disease. Additionally, vaccinations should be administered according to an individually tailored plan to avoid overwhelming the puppies' immune system. ","haufig_gestellte_fragen_faqs":"
    \n \t
  1. What is canine juvenile cellulitis?<\/b> Canine juvenile cellulitis, also known as sterile granulomatous dermatitis and lymphadenitis, is an inflammatory skin disease that primarily affects puppies. It manifests through swelling, pustules, and skin lesions, often on the face and ears, and can be painful. <\/li>\n \t
  2. What symptoms does a dog with this disease show?<\/b> Typical symptoms are swelling in the face, particularly around the eyes and lips, pustules, hair loss, and crust formation. In some cases, fever, enlarged lymph nodes, and general lethargy may also occur. <\/li>\n \t
  3. Which dogs are most commonly affected?<\/b> The disease occurs primarily in young puppies between 3 and 4 months of age. Certain breeds, such as Golden Retrievers, Labrador Retrievers, and Dachshunds, appear to be more commonly affected, suggesting a genetic predisposition. <\/li>\n \t
  4. How is canine juvenile cellulitis diagnosed?<\/b> Diagnosis is usually made through a combination of clinical examination, medical history, and special tests such as skin biopsies. The biopsy can help identify the typical inflammatory cell infiltrates that characterize the disease. <\/li>\n \t
  5. Is the disease contagious?<\/b> No, canine juvenile cellulitis is not contagious. It is not caused by bacteria, viruses, or parasites and cannot be transmitted from dog to dog or to humans. <\/li>\n \t
  6. How is the disease treated?<\/b> Treatment typically involves the administration of corticosteroids to reduce inflammation. In some cases, antibiotics may also be prescribed to treat secondary bacterial infections. Treatment should be supervised by a veterinarian. <\/li>\n \t
  7. Can affected puppies recover completely?<\/b> Yes, with the right treatment, most puppies can recover completely. Symptoms can improve significantly within weeks to months, although relapses can occur in some cases. <\/li>\n \t
  8. Are there any long-term consequences for affected dogs?<\/b> Generally, there are no long-term health consequences if the disease is treated early. However, in some cases, scars or pigment changes may remain on the skin. <\/li>\n \t
  9. Can the disease occur in adult dogs?<\/b> Canine juvenile cellulitis occurs almost exclusively in puppies. In adult dogs, the disease occurs very rarely and could indicate an underlying condition. <\/li>\n \t
  10. How can the risk of this disease be minimized?<\/b> Since the exact cause is not fully understood, there is no specific prevention. However, good general care and health monitoring of puppies, including regular veterinary examinations, can help detect and treat the disease early. <\/li>\n<\/ol>","literaturangaben":"
      \n \t
    • Bajwa, J. (2022). Juvenile cellulitis (juvenile sterile granulomatous dermatitis and lymphadenitis) in a 9-week-old puppy treated with prednisolone-cyclosporine combination drug therapy. Canadian Veterinary Journal, 63(3), 277\u2013281. <\/li>\n \t
    • White, S. D., Rosychuk, R. A., Scott, K. V., Hargis, A. M., & Jonas, L. (1989). Juvenile cellulitis in dogs: 15 cases (1979\u20131988). Journal of the American Veterinary Medical Association, 195(11), 1609\u20131611. <\/li>\n \t
    • Reimann, K. A., Evans, M. G., Chalifoux, L. V., Turner, S., DeBoer, D. J., King, N. W., & Letvin, N. L. (1989). Clinicopathologic characterization of canine juvenile cellulitis. Veterinary Pathology, 26(6), 499\u2013504. https:\/\/doi.org\/10.1177\/030098588902600607<\/li>\n \t
    • Inga, A., Griffeth, G. C., Ferrer, L., & Miller, W. H. (2020). Sterile granulomatous dermatitis and lymphadenitis (juvenile cellulitis) in adult dogs: A retrospective analysis of 90 cases (2004\u20132018). Veterinary Dermatology, 31(3), 219\u2013e54. https:\/\/doi.org\/10.1111\/vde.12827<\/li>\n \t
    • Park, C., Yoo, J. H., Kim, H. J., Kang, B. T., & Park, H. M. (2010). Combination of cyclosporin A and prednisolone for juvenile cellulitis concurrent with hindlimb paresis in three English Cocker Spaniel puppies. Journal of Veterinary Medical Science, 72(10), 1265\u20131271. https:\/\/doi.org\/10.1292\/jvms.09-0476<\/li>\n \t
    • Santoro, D., & Campbell, K. L. (2011). Use of ciclosporin in a dog with canine juvenile sterile granulomatous dermatitis and lymphadenitis. Veterinary Dermatology, 22(3), 287\u2013288. https:\/\/doi.org\/10.1111\/j.1365-3164.2010.00953.x<\/li>\n \t
    • Hutchings, S. M. (2003). Juvenile cellulitis in a puppy. Canadian Veterinary Journal, 44(5), 418\u2013419. <\/li>\n<\/ul>","symptome_ausgeblendet":"","erganzungen":"","faq":[{"frage":"1. What is canine juvenile cellulitis?","antwort":"Canine juvenile cellulitis, also known as sterile granulomatous dermatitis and lymphadenitis, is an inflammatory skin condition that primarily affects puppies. It manifests as swelling, pustules, and skin lesions, often on the face and ears, and can be painful. -"},{"frage":"2. What symptoms does a dog with this disease show?","antwort":"Typical symptoms include swelling in the face, especially around the eyes and lips, pustules, hair loss, and crusting. In some cases, fever, enlarged lymph nodes, and general lethargy may also occur. -"},{"frage":"3. Which dogs are most commonly affected?","antwort":"The disease mainly occurs in young puppies between 3 weeks and 4 months of age. Certain breeds, such as Golden Retrievers, Labrador Retrievers, and Dachshunds, seem to be affected more frequently, suggesting a genetic predisposition. -"},{"frage":"4. How is canine juvenile cellulitis diagnosed?","antwort":"The diagnosis is usually made through a combination of clinical examination, medical history, and special tests such as skin biopsies. The biopsy can help identify the typical inflammatory cell infiltrates characteristic of the disease. -"},{"frage":"5. Is the disease contagious?","antwort":"No, canine juvenile cellulitis is not contagious. It is not caused by bacteria, viruses, or parasites and cannot be transmitted from dog to dog or to humans. -"},{"frage":"6. How is the disease treated?","antwort":"Treatment usually involves the administration of corticosteroids to reduce inflammation. In some cases, antibiotics may also be prescribed to treat secondary bacterial infections. Treatment should be supervised by a veterinarian. -"},{"frage":"7. Can affected puppies fully recover?","antwort":"Yes, with the right treatment, most puppies can make a full recovery. Symptoms can improve significantly within weeks to months, although relapses can occur in some cases. -"},{"frage":"8. Are there long-term consequences for affected dogs?","antwort":"Generally, there are no long-term health consequences if the disease is treated early. However, in some cases, scarring or pigment changes may remain on the skin. -"},{"frage":"9. Can the disease occur in adult dogs?","antwort":"Canine juvenile cellulitis occurs almost exclusively in puppies. In adult dogs, the condition is very rare and could indicate another underlying disease. -"},{"frage":"10. How can the risk of this disease be minimized?","antwort":"Since the exact cause is not fully understood, there is no specific prevention. However, good general care and health monitoring of puppies, including regular veterinary check-ups, can help detect and treat the disease early. 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